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Castration Delays Epigenetic Aging And Feminizes DNA - ELife

Jul 06, 2021  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and

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Generation of vascularized brain organoids to study ... - eLife

Posted: (53 years ago) May 04, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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About | eLife

Posted: (53 years ago) eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State …

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Point of View: Tell me a story | eLife

Posted: (53 years ago) Aug 06, 2019  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Expansion and contraction of resource allocation in sensory …

Posted: (53 years ago) Aug 04, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Magazine | eLife

Posted: (53 years ago) Aug 03, 2022  · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation …

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Association analyses of host genetics, root-colonizing microbes

Posted: (53 years ago) Jul 27, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Latest research | eLife

Posted: (53 years ago) Aug 01, 2022  · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation …

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Parallel processing, hierarchical transformations, and sensorimotor ...

Posted: (53 years ago) Aug 11, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Compact and highly active next-generation libraries for CRISPR ... - eLife

Posted: (53 years ago) Sep 23, 2016  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Open Knowledge Maps: A visual interface to the world’s ... - eLife

Posted: (53 years ago) Feb 26, 2020  · Open Knowledge Maps is an open infrastructure based on the principles of open science: source code, content and data are shared under an open license.We are a building block of the open discovery infrastructure, with which we extensively collaborate.As a community-driven initiative, we develop our services in a participatory process together with our …

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Early-Career Advisory Group: Meet our new members for 2022

Posted: (53 years ago) Aug 03, 2022  · Add a comment + Open annotations. The current annotation count on this page is being calculated.. Earlier this year, we put a call out to the early-career researcher community to join our Early-Career Advisory Group (ECAG) and help improve science culture and communication.. Following the application process, our new ECAG members were elected by …

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Research Articles | eLife

Posted: (53 years ago) Aug 12, 2022  · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation …

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Adaptive Immunity: Maintaining naivety of T cells | eLife

Posted: (53 years ago) Aug 03, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Mechanism of the cadherin-catenin F-actin catch bond interaction

Posted: (53 years ago) Aug 01, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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The temporal representation of experience in subjective mood

Posted: (53 years ago) Jun 15, 2021  · The two principal models, Recency and Primacy, are described in Figure 1B.Both models consider a cumulative and discounted impact of the expectation term on mood, as shown in Figure 1B, Equation 1 (Equations 6–8 in Materials and methods provide the complete formulation of these models). The Recency model represents the standard models applied in …

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The evolution of a counter-defense mechanism in a virus …

Posted: (53 years ago) Aug 04, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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STAG2 promotes the myelination transcriptional programin ...

Posted: (53 years ago) Aug 12, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Local field potentials reflect cortical population dynamics in a …

Posted: (53 years ago) 2 days ago · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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trim-21 promotes proteasomal degradation of CED-1 for …

Posted: (53 years ago) Aug 05, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Tension-driven multi-scale self-organisation in human iPSC ... - eLife

Posted: (53 years ago) Aug 03, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Integrated analyses of growth differentiation Factor-15 ... - eLife

Posted: (53 years ago) Aug 02, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Fermentation: Teaming up to make kombucha | eLife

Posted: (53 years ago) Aug 11, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Transferrin receptor 1-mediated iron uptake regulates bone mass …

Posted: (53 years ago) Jun 27, 2022  · Bone mass and structure in adults are maintained by constant bone remodeling with balanced bone formation by osteoblasts and bone resorption by osteoclasts (Zaidi, 2007; Siddiqui and Partridge, 2016).Under pathological conditions, however, excessive bone resorption caused by either increased number or exaggerated activities of osteoclasts leads to bone loss …

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PLK4 drives centriole amplification and apical surface area …

Posted: (53 years ago) 2 days ago · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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The VINE complex is an endosomal VPS9-domain GEF and SNX …

Posted: (53 years ago) Aug 08, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Prolonged β-adrenergic stimulation disperses ryanodine ... - eLife

Posted: (53 years ago) Aug 01, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Perception of a conserved family of plant signalling peptides by …

Posted: (53 years ago) May 26, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Structures of topoisomerase V in complex with DNA reveal …

Posted: (53 years ago) 2 days ago · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Research Culture: Highlighting the positive aspects of being a PhD ...

Posted: (53 years ago) Jul 26, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Ubiquitination drives COPI priming and Golgi SNARE localization

Posted: (53 years ago) Jul 29, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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A pulse-chasable reporter processing assay for mammalian …

Posted: (53 years ago) Aug 08, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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PH domain-mediated autoinhibition and oncogenic activation of Akt

Posted: (53 years ago) 2 days ago · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Transgenic quails reveal dynamic TCF/β-catenin signaling ... - eLife

Posted: (53 years ago) Jul 14, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Cancer type classification using plasma cell-free RNAs derived

Posted: (53 years ago) Jul 11, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Temporal analysis of enhancers during mouse cerebellar …

Posted: (53 years ago) Aug 09, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Evolution: Poor eyesight reveals a new vision gene | eLife

Posted: (53 years ago) Aug 05, 2022  · The product of the Serpine3 gene belongs to a family of proteins secreted into the extracellular space and implicated in blood clotting, neuroprotection and some human diseases (Law et al., 2006; Barnstable and Tombran-Tink, 2004).To better understand the role Serpine3 plays in vision, the team carried out functional experiments in zebrafish, as their retinas are …

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Robotic search for optimal cell culture in regenerative medicine

Posted: (53 years ago) Jun 28, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Selenocyanate derived Se-incorporation into the Nitrogenase Fe

Posted: (53 years ago) Jul 29, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Brain: Connecting the lines after a stroke | eLife

Posted: (53 years ago) Jul 28, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Cryo-EM structures reveal that RFC recognizes both the 3 ... - eLife

Posted: (53 years ago) Jul 13, 2022  · Cryo-EM shows a 5’ DNA site on the RFC clamp loader, in addition to the 3’ site, and biochemical study shows the 5’ site facilitates PCNA loading onto gaps, consistent with genetics indicating the 5’ DNA site facilitates gap repair.

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Circadian oscillations in Trichoderma atroviride and the role of …

Posted: (53 years ago) Aug 11, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Enteroendocrine cell types that drive food reward and aversion

Posted: (53 years ago) Aug 01, 2022  · Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and ...

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Arl15 upregulates the TGFβ family signaling by promoting the

Posted: (53 years ago) Jul 14, 2022  · To explore which domain or region of Smad4 interacts with active Arl15, we prepared GST-fused Smad4 fragments (Figure 1—figure supplement 1b) and tested if they pull down Arl15-AL-GFP expressed in cell lysate (Figure 1e; Figure 1—figure supplement 1c).We found that the Smad4-MH2 domain, but not the MH1 domain, is sufficient to interact with Arl15 …

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